From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat
Organ | Weight (Kg) | ECF water(L) | Flow (L/min) | ACE Tiss/Plasma | Ramiprialat Ps (min-1) | Ramiprilat fu_cell | Ramipril Ps (min-1) | Ramipril fu_cell |
---|---|---|---|---|---|---|---|---|
Blood | 5.5 | 2.68345 | Â | 0.52 | 0 | ---- | Â | Â |
liver | 1.8 | 0.2898 | 0.45 | 1.37 | Adjustable | 1 | infinite | 0.1 |
portal | 1.5 | 0.351 | 1.125 | 2.0 | 0 | ---- | 0.05 | 0.5 |
muscle | 26 | 3.042 | 0.585 | 1.0 | 0 | ---- | 0.05 | 0.5 |
kidney | 0.31 | 0.04092 | 1.24 | 5.62 | Adjustable | 10 | infinite | 0.01 |
brain | 1.4 | 0 | 0.784 | 0.8 | 0 | ---- | 0.05 | 0.5 |
heart | 0.33 | 0.066 | 0.264 | 1.7 | 0 | ---- | 0.05 | 0.5 |
lung | 0.536 | 0.08576 | 5.6184 | 34 | 0 | ---- | 0.05 | 0.5 |
skin | 2.6 | 1.092 | 0.26 | 3.51 | 0 | ---- | 0.05 | 0.5 |
tendon | 3 | 2.55 | 0.03 | 7.23 | 0 | ---- | 0.05 | 0.5 |
other | 5.524 | 3.75632 | 0.1104 | 5.79 | 0 | ---- | 0.05 | 0.5 |
bone | 4 | 0 | 0 | 0 | 0 | ---- | 0 | 0.5 |
adipose | 17.5 | 3.5 | 0.7385 | 6.81 | 0 | ---- | 0.05 | 0.5 |
Total | 70 | 17.4572 | 5.5877 | Â | Â | Â | Â | Â |