Figure 18From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilatTop: model plasma (black), heart (red) and skeletal muscle (green) ramiprilat concentration following oral ramipril in a subject with average PBPK parameters. Bottom: fraction of C site (left) and N site (right) ACE in plasma (black), heart (red) and skeletal muscle (green) that is inhibited by ramiprilat following oral ramipril in same average subject.Back to article page