Figure 1From: Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilatPBPK model of the pharmacokinetics of prodrug ramipril (R) and active drug ramiprilat (D). The figure schematically illustrates the events in three different tissues (typical "tissue", the liver and the kidney), the intestinal absorption, the renal clearance and enterohepatic recirculation.Back to article page