Pharmacokinetics of isoflavones, daidzein and genistein, after ingestion of soy beverage compared with soy extract capsules in postmenopausal Thai women

Table 2 Individual and mean pharmacokinetic parameters of daidzein following a single dose of orally administered soy beverage (B) and soy extract capsules (C).

Subj No.	C_max (ng/ml)		C_max/Dose¹		AUC_0–32 (ng.h/ml)		AUC_0–32/Dose¹		AUC_0-∝ (ng.h/ml)		AUC_0-∝/Dose¹		T_max (h)		t_1/2 (h)
	B	C	B	C	B	C	B	C	B	C	B	C	B	C	B	C
1	67.42	60.73	7.27	7.80	354.62	650.40	38.25	83.49	496.21	722.51	53.53	92.75	6	6	6.06	8.04
2	142.17	56.33	15.34	7.23	1142.38	931.84	123.23	119.62	1206.09	1024.24	130.11	131.48	6	1	6.74	6.02
3	64.95	76.70	7.01	9.85	1118.40	1117.20	120.65	143.41	1704.60	1171.78	183.88	150.42	8	6	19.80	6.85
4	132.30	124.43	14.27	15.97	1336.29	1356.49	144.15	174.13	1402.26	1427.11	151.27	183.20	6	6	6.70	6.91
5	77.66	93.20	8.38	11.96	1293.52	1251.35	139.54	160.64	1483.69	1561.72	160.05	200.48	8	10	9.94	10.50
6	105.65	142.82	11.40	18.33	1409.24	1378.43	152.02	176.95	1533.26	1450.55	165.40	186.21	10	6	6.21	6.86
7	160.86	125.37	17.35	16.09	1576.65	1669.28	170.08	214.28	1761.36	1721.18	190.01	220.95	4	6	8.48	5.97
8	102.77	74.08	11.09	9.51	1158.07	1090.36	124.93	139.97	1227.07	1149.04	132.37	147.50	6	6	6.85	6.76
9	45.34	105.77	4.89	13.58	300.89	849.39	32.46	109.04	340.35	876.40	36.72	112.50	4	6	3.46	4.40
10	52.98	84.74	5.72	10.88	401.82	579.95	43.35	74.45	533.03	761.42	57.50	97.74	1	6	4.82	4.38
11	99.98	87.38	10.79	11.22	1291.80	1546.66	139.35	198.54	1455.80	1705.46	157.04	218.93	8	10	6.59	7.63
12	103.60	120.64	11.18	15.49	578.60	909.87	62.42	116.80	665.06	971.69	71.74	124.74	4	6	6.49	5.71
Mean	96.31	96.02^ND	10.39	12.33	996.86	1110.94^ND	107.54	142.61*	1150.73	1211.93^ND	124.14	155.57*	5.92	6.25	7.68	6.67
SD	36.18	27.71	3.90	3.56	455.69	342.26	49.16	43.94	504.94	354.46	54.47	45.50	2.43	2.26	4.14	1.65

¹Pharmacokinetic parameters adjusted for oral administered dose. ND = statistical analysis was not performed due to differences in oral administered doses between both preparations, *Statistical significance (p < 0.05) compared to corresponding values of soy extract capsules.