Patient Profile | Dose (mg) | Dosage Interval (hours) | T1/2 (hrs) | k (hr-1) | AUC0-Ï„* (Ï„ = dosage interval) (mg.hr/L) | TBC (Dose/AUC) (L/hr) | Vdss (L) |
---|---|---|---|---|---|---|---|
1.A | 400 | 12 | 35.2 | 0.020 | 35.4 | 11.3 | 524 |
1.B | 400 | 12 | 39.4 | 0.018 | 38.3 | 10.4 | 555 |
Mean | Â | Â | 37.3 | 0.019 | 36.8 | 10.9 | 539 |
2.A | 200 | 12 | 5.15 | 0.135 | 15.2 | 13.2 | 104 |
2.B | 200 | 12 | 13.8 | 0.050 | 16.5 | 12.2 | 215 |
2.C | 400 | 12 | 12.4 | 0.056 | 51.8 | 7.72 | Â |
Mean | Â | Â | 10.5 | 0.080 | Â | 11.0 | 160 |
3.A | 400 | 12 | 5.97 | 0.116 | 38.9 | 10.3 | 79.5 |
3.B | 400 | 12 | 7.50 | 0.092 | 40.2 | 10.0 | 97.3 |
Mean | Â | Â | 6.73 | 0.104 | 39.5 | 10.1 | 88.4 |
4.A | 400 | 24 | 24.7 | 0.028 | 129 | 3.10 | 111 |
4.B | 400 | 12 | 27.2 | 0.026 | 81.5 | 4.91 | Â |
Mean | Â | Â | 25.9 | 0.027 | Â | 4.00 | Â |
5.A | 400 | 12 | 8.44 | 0.082 | 40.4 | 9.90 | 107 |
5.B | 400 | 12 | 5.77 | 0.120 | 37.8 | 10.6 | 81.1 |
5.C | 400 | 12 | 6.80 | 0.102 | 40.9 | 9.78 | 88.2 |
Mean | Â | Â | 7.00 | 0.101 | 39.7 | 10.1 | 92.2 |
6.A | 400 | 24 | 14.0 | 0.050 | 43.4 | 9.22 | 175 |
6.B | 400 | 12 | 14.7 | 0.047 | 54.0 | 7.40 | 151 |
6.C | 400 | 12 | 16.5 | 0.042 | 49.6 | 8.06 | Â |
Mean | Â | Â | 15.0 | 0.046 | Â | 8.23 | 163 |
7.A | 400 | 24 | 15.1 | 0.046 | 50.6 | 7.91 | 164 |
7.B | 400 | 12 | 10.4 | 0.067 | 39.4 | 10.1 | 139 |
Mean | Â | Â | 12.7 | 0.056 | Â | 9.00 | 151 |