BMC Clinical Pharmacology

Table 2 Pharmacokinetic parameters for total phenoxodiol following a single bolus dose of 5 mg/kg infused intravenously over 5 minutes.

From: Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer

Patient	Kel	T1/2 (h)	AUC_0-t (μg.h/ml)	AUC_0-inf (μg.h/ml)	Cl (L/h)	Vd (L/kg)
1	0.21	3.33	27.10	37.76	0.06	0.31
2	0.25	2.71	33.47	34.64	0.05	0.21
3	0.37	1.85	7.45	7.93	0.29	0.80
4	0.29	2.32	14.19	16.13	0.15	0.50
5	0.35	1.98	21.12	22.83	0.15	0.45
6	0.09	6.98	10.37	10.37	0.16	1.60
Mean ± SD	0.26 ± 0.10	3.19 ± 1.93	18.93 ± 10.11	21.61 ± 12.45	0.15 ± 0.08	0.64 ± 0.51

Abbreviations are the same as for Table 1.

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